Priorities: Remember to save Kimimaro's mystery for 2/4 and 4/4. 2/4 to kill Mifune and 4/4 to kill Fuu. Mifune's mystery will hit for 20k+ and kill one ninja for sure, you dont want that to happen. As for Fuu, the obvious, lol (Save iruka's interrupt for Fuu, kill her off with Kimi's mystery).. Kimimaro's mystery is a combo starter so you want to save them to interrupt mystery or to kill.

Problem with this team is if you have a weaker team, sasuke and iruka might die early and may post a problem.

P.S You can let Mei's mystery hit you if you want, it doesnt hurt at all.

IGN: Kurine, S498.