A few points:

1. You don't need reserve seal or whatever for GNW Tenten team, just run with healing standard and enhancement of water ninja.

2. Healing tips stack with one another, meaning that Tsunade[5th hokage] just boosts it ever further (40% + 45%, legit).

3. Poison is too easy to apply as Azure Fang, and it's not limited to that ninja only, meaning that if the enemy can't clear debuffs, they will have 4 stacks on them from turn 1.

4. Standard attacks pack way too much utility: a heal that clears all debuffs / acupuncture + knockdown / high float + high damage + damage to self making her super good in all fronts with no clear weakness.

5. Passives are overloaded, you can run both healing tips and poison at the same time or if you feel like you have enough healing you can just make your critical hits cause chaos.

6. Highest raw stats our of all main characters by far, she can tank as well as earth main, provide support and healing, deal good damage and all that while having more HP and defenses to work with.

7. Kakashi is by far one of the most useless characters in this game, rocking a pitiful stat line, terrible mystery (single target, causes low float, based on taijutsu with low damage), chases are "OK" (low damage on both, status effects are nice but they're single target), one of the weakest clones in the game (which he can't recreate after it's killed) and skill breaks make his mystery somewhat comparable to Suigetsu's, which shows you how good it is.

8. Ninja power distribution seems very dumb in general, after looking at growth stats, Iruka has better stats than 90% of ninja if not all, now while the game does not have to be accurate compared to the anime or whatever, a bit of thought would have been nice. I got Yagura the other day, upgraded him just to see how his stats go, and to my surprise his stats are probably the worst I've seen so far in this game, his only decent stat being resistance, which he does not use in combat in any way (shields for example). So he's basically set to be a support, and a lousy one at that considering the only things he brings to the table are a bit of chakra each round and the ability to create a weak clone of one enemy ninja (which is nice but usually not practical for anything but stealing barriers or getting some buffs.